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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Genome-wide Association Studies-GWAS01:11

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Related Experiment Video

Updated: May 28, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Vitamin D-gene interactions in multiple sclerosis.

Antonio J Berlanga-Taylor1, Giulio Disanto, George C Ebers

  • 1Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, UK.

Journal of the Neurological Sciences
|October 18, 2011
PubMed
Summary
This summary is machine-generated.

Vitamin D deficiency is linked to multiple sclerosis (MS). This review explores how vitamin D and its receptor (VDR) interact with MS-associated genes, revealing molecular mechanisms for this connection.

Related Experiment Videos

Last Updated: May 28, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

  • Neuroimmunology
  • Endocrinology
  • Molecular Biology

Background:

  • Vitamin D's established role in calcium homeostasis.
  • Emerging evidence highlights vitamin D's broader physiological functions and disease relevance.
  • A known association exists between vitamin D deficiency and multiple sclerosis (MS), but underlying molecular mechanisms remain unclear.

Purpose of the Study:

  • To review the molecular mechanisms linking vitamin D to multiple sclerosis (MS).
  • To emphasize the interaction between vitamin D and genes associated with MS.
  • To provide a biological basis for the observed association between vitamin D status and MS risk.

Main Methods:

  • Review of existing literature on vitamin D, vitamin D receptor (VDR), and multiple sclerosis (MS).
  • Analysis of recent technological advancements providing insights into vitamin D's biological actions.
  • Focus on the interplay between vitamin D signaling pathways and MS-associated genetic factors.

Main Results:

  • Vitamin D exerts its effects significantly through the vitamin D receptor (VDR).
  • Interactions between vitamin D and MS-associated genes are crucial for understanding the disease link.
  • Recent research elucidates the molecular pathways involved.

Conclusions:

  • The interaction between vitamin D and MS-associated genes offers a biological explanation for the vitamin D-MS risk association.
  • Understanding these molecular interactions is key to further research in MS.
  • Vitamin D's role in MS pathogenesis warrants continued investigation.