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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

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Published on: May 14, 2013

Sirolimus- vs. paclitaxel-eluting stent to coronary intervention in dialysis patients

Daisuke Kamoi1, Hideki Ishii, Hiroshi Takahashi

  • 1Department of Cardiology, Nagoya Kyoritsu Hospital, Nagoya, Japan.

International Journal of Cardiology
|October 18, 2011
PubMed

Insights

Sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) showed similar restenosis rates in hemodialysis patients undergoing percutaneous coronary intervention. Patients on hemodialysis remain at high risk for restenosis despite drug-eluting stent treatment.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Nephrology

Background:

  • Patients on maintenance hemodialysis (HD) face elevated restenosis risk post-percutaneous coronary intervention (PCI).
  • Drug-eluting stents (DES) are used to mitigate this risk, but comparative data in HD patients is limited.

Purpose of the Study:

  • To compare the efficacy of sirolimus-eluting stents (SES) versus paclitaxel-eluting stents (PES) in preventing restenosis.
  • To evaluate angiographic outcomes in hemodialysis patients with coronary artery disease treated with SES or PES.

Main Methods:

  • 100 maintenance hemodialysis patients undergoing PCI were randomized to SES or PES.
  • Follow-up angiographic outcomes were assessed at 8 months.

Main Results:

  • No significant difference in angiographical restenosis rates between SES (19.7%) and PES (20.0%) groups (p=0.97).
  • Similar late loss and no significant differences in major adverse cardiac events or target lesion revascularization between groups.

Conclusions:

  • Both SES and PES demonstrate comparable angiographic outcomes in hemodialysis patients at 8-month follow-up.
  • Hemodialysis patients remain at high risk for restenosis, even after treatment with current DES.
Abstract

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