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[Expression of c-kit and Cx43 in neonates with spontaneous gastric perforation]
Li-Na Xia1, Zhi-Qiang Wang, Zong-Min Wang
1Department of Pathology, Yuying Children's Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China.
Objective:
To study the clinical significance of interstitial cell of Cajal (ICC) in spontaneous neonatal gastric perforation by examining the expression of c-kit and Cx43 in neonates with this disorder.
Methods:
The gastric specimens of 19 cases of neonatal gastric perforation from 2001 to 2010 and 8 cases of accidental death without digestive tract malformations (control) were collected. Immunohistochemical staining was employed to examine the expression of c-kit and Cx43 (immunomarkers of ICCs) in gastric tissues.
Results:
The muscular layer of the stomach wall became thinner or deficient in the gastric perforation group. C-kit and Cx43 positive cells in gastric tissues decreased significantly in the gastric perforation group compared with those in the control group (P<0.01).
Conclusions:
The development of spontaneous neonatal gastric perforation is associated with the decreased quantity of ICCs and damaged gap junction structure of the stomach wall.
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