Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 28, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Peptide receptor-based selective dinitrotoluene detection using a microcantilever sensor.

Kyo Seon Hwang1, Min Hyuck Lee, Juhee Lee

  • 1Center for Biomicrosystem, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea. kshwang@kist.re.kr

Biosensors & Bioelectronics
|October 18, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neoadjuvant Danburstotug (IMC-001) therapy in gastric, esophageal, and hepatocellular carcinoma: the NeoChance phase II study.

NPJ precision oncology·2026
Same author

Optimal Sampling Site for the Diagnosis of <i>Helicobacter pylori</i> Infection with the Rapid Urease Test: A Prospective Cohort Study.

Gut and liver·2026
Same author

Enhancing foundation model transfer for prostate cancer detection with patch-level contrastive learning.

NPJ digital medicine·2026
Same author

Clinical outcomes of endoscopic balloon dilatation for postoperative anastomotic stricture after distal gastrectomy.

Surgical endoscopy·2026
Same author

Comparison of the efficacy and safety of endoscopic and fluoroscopic balloon dilatation in benign esophageal strictures.

The Korean journal of internal medicine·2026
Same author

Transcriptome-based Deep Learning Model for Predicting Gemcitabine and Cisplatin Chemotherapy Response in Urothelial Carcinoma: Development and External Validation.

Cancer genomics & proteomics·2026
Same journal

Recent developments of textile-based triboelectric nanogenerators for smart sports applications.

Biosensors & bioelectronics·2026
Same journal

One-Tube RPA-CRISPR-Cas13a assay with rational design for single-molecule detection of waterborne viruses in drinking water treatment.

Biosensors & bioelectronics·2026
Same journal

AI-driven photophysics-aware design of fluorescent probes with applications in α-synuclein biosensing and inhibitor screening.

Biosensors & bioelectronics·2026
Same journal

Three-dimensional helical integration of high-density linear microelectrode arrays and their cross-tissue applications.

Biosensors & bioelectronics·2026
Same journal

Integration of electrochemical sensors in organ-on-a-chip microfluidic platforms: Advances and perspectives.

Biosensors & bioelectronics·2026
Same journal

DNN-PURE: A deep neural network approach to paper-based urea sensing.

Biosensors & bioelectronics·2026
See all related articles

Researchers developed a peptide-based microcantilever sensor for detecting 2,4-dinitrotoluene (DNT) vapor. This novel sensor achieves parts per billion sensitivity, paving the way for advanced chemical vapor monitoring systems.

Area of Science:

  • Chemical Sensors
  • Nanotechnology
  • Biomolecular Recognition

Background:

  • Peptides offer specific molecular recognition capabilities for sensor development.
  • Microcantilever-based sensors provide high sensitivity for detecting minute amounts of analytes.
  • Existing methods for detecting explosive vapors like 2,4-dinitrotoluene (DNT) often require complex instrumentation.

Purpose of the Study:

  • To investigate the use of a specific peptide as a receptor molecule for detecting 2,4-dinitrotoluene (DNT) vapor.
  • To develop a micro/nanosensor capable of real-time DNT detection in the gas phase.
  • To evaluate the sensitivity and specificity of peptide-immobilized microcantilevers for DNT sensing.

Main Methods:

  • Immobilizing a specific peptide onto microcantilever surfaces.

More Related Videos

Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System
07:32

Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System

Published on: January 30, 2019

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

Related Experiment Videos

Last Updated: May 28, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System
07:32

Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System

Published on: January 30, 2019

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

  • Measuring changes in the resonant frequency of the microcantilevers upon exposure to DNT vapor.
  • Comparing the response of DNT-specific peptide sensors with non-specific peptide sensors.
  • Calculating the limit of detection (LOD) based on experimental noise levels.

    • Main Results:

    • The peptide-immobilized microcantilever sensor successfully detected 2,4-dinitrotoluene (DNT) vapor at concentrations as low as parts per billion (ppb).
    • A significant change in resonant frequency was observed upon binding of DNT to the specific peptide receptor.
    • No significant resonant frequency change was observed with non-specific peptide-immobilized microcantilevers, indicating high specificity.
    • The experimentally determined limit of detection (LOD) was found to be 431 parts per trillion (ppt).

    Conclusions:

    • Peptide receptors are highly promising for developing sensitive and specific gas-phase chemical sensors.
    • Microcantilever technology combined with peptide receptors can form the basis of an artificial olfactory system or electronic nose.
    • This approach holds potential for monitoring various chemical vapors, including explosive compounds and volatile organic compounds (VOCs).