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Gestational age-specific reference intervals for routine haemostatic assays during normal pregnancy.
Junjie Liu1, EnWu Yuan, Li Lee
1Department of Clinical Laboratory, Zhengzhou University Third Hospital, Zhengzhou, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 18, 2011
Summary
This study establishes crucial gestational age-specific reference ranges for coagulation analytes in pregnant women. These new ranges improve clinical decision-making during pregnancy by accounting for hypercoagulable states.
Area of Science:
- Clinical Chemistry
- Hematology
- Obstetrics
Background:
- Pregnancy involves a hypercoagulable state, making standard coagulation reference ranges suboptimal.
- Existing data on gestational age-specific reference intervals for coagulation parameters are limited.
- Accurate clinical decisions during pregnancy necessitate tailored reference ranges.
Purpose of the Study:
- To establish gestational age-specific reference intervals for key coagulation analytes.
- To provide a basis for improved clinical interpretation of coagulation tests in pregnant individuals.
Main Methods:
- Assayed prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen (Fib) in 1130 pregnant women.
- Utilized an ACL TOP automatic coagulation analyzer for plasma sample analysis.
- Excluded outliers to ensure data integrity for reference range determination.
Main Results:
- Provided specific reference ranges for PT, TT, APTT, and Fib across multiple gestational age groups (≤12, 13-20, 21-27, 28-35, 36-42 weeks).
- Demonstrated variations in coagulation analyte ranges correlating with advancing gestational age.
- Detailed numerical ranges for each analyte at different stages of pregnancy.
Conclusions:
- Established gestational age-specific reference intervals for PT, TT, APTT, and Fib.
- These intervals can aid clinicians in making more accurate clinical decisions during pregnancy.
- The established ranges warrant validation for adoption in other laboratory settings.
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