Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells
Dong Jo Chang1, Mi Young Jeong, Jiho Song
1College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Bioorganic & Medicinal Chemistry Letters
|October 18, 2011
Abstract:
1,3,4-Oxadiazole derivatives were found to enhance astrocyte differentiation in rat fetal neural stem cells (NSCs). Differentiation activity was assessed by immunocytochemistry and analysis of mRNA expression of astrocyte markers, GFAP and S100. Compounds 7 and 8 showed approximately a two-fold increase in astrocyte differentiation without engagement of neuronal differentiation and detectable cytotoxicity.
