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Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
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Role of extracellular DNA oxidative modification in radiation induced bystander effects in human endotheliocytes

Svetlana V Kostyuk1, Aleksei V Ermakov, Anna Yu Alekseeva

  • 1Research Centre for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia.

Mutation Research
|October 18, 2011
PubMed

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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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