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Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination
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Streptococcus pneumoniae serotypes in Utah adults at the end of the PCV7 era

Brian A Kendall1, Kristin K Dascomb, Rajesh R Mehta

  • 1Department of Medicine, University of Utah, Salt Lake City, UT, United States. augustkendall@gmail.com

Vaccine
|October 18, 2011
PubMed

Insights

Pediatric pneumococcal conjugate vaccine (PCV) use in Utah is linked to adult invasive pneumococcal disease (IPD) serotypes. PCV13 vaccination in children may significantly reduce adult IPD cases.

Area of Science:

  • Infectious Diseases
  • Vaccinology
  • Epidemiology

Background:

  • Heptavalent pneumococcal conjugate vaccine (PCV7) reduced invasive pneumococcal disease (IPD) nationally.
  • Utah children show serotype replacement and increased parapneumonic empyema post-PCV7.
  • The impact of pediatric vaccination on adult IPD in Utah remains unexamined.

Purpose of the Study:

  • To determine the serotype distribution of adult IPD in Utah.
  • To compare adult IPD serotypes with pediatric IPD serotypes.
  • To assess the potential impact of pediatric PCV13 vaccination on adult IPD.

Main Methods:

  • Identified 117 adult IPD cases from November 2009 to October 2010.
  • Serotyped 61 (52%) of stored adult isolates.
  • Compared adult IPD serotypes with pediatric isolates from 2009-2010.

Main Results:

  • PCV7 serotypes were rare in both adult (3%) and pediatric (3%) IPD cases.
  • Emerging PCV13 serotypes (3, 7F, 19A) predominated in adult (63%) and pediatric (56%) IPD.
  • Most adult isolates (84%) were covered by the 23-valent polysaccharide vaccine, and 66% by PCV13.

Conclusions:

  • Adult and pediatric IPD serotypes in Utah are closely associated.
  • PCV13 vaccination in Utah children is expected to significantly reduce adult IPD.
  • This suggests a potential herd effect of pediatric vaccination on the adult population.

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