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CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans

Petra E Spies1, Diane Slats, Marcel G M Olde Rikkert

  • 1Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, and Alzheimer Centre, Nijmegen, The Netherlands. PetraESpies@gmail.com

Neuroscience Letters
|October 18, 2011
PubMed

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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