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Plasma concentrations of interleukin-6, C-reactive protein, tumor necrosis factor-α and matrix metalloproteinase-9 in

Dan Wen1, Xian-Liang Zhou, Jian-Jun Li

  • 1Department of Cardiology, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 18, 2011
PubMed

Insights

Inflammation plays a key role in aortic dissection (AD). This study found elevated levels of interleukin-6 (IL-6), C-reactive protein (CRP), and matrix metalloproteinase-9 (MMP-9) in AD patients, confirming their association with the condition.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Biomarker Discovery

Background:

  • The role of inflammation in aortic dissection (AD) remains incompletely understood.
  • Investigating inflammatory markers like IL-6, CRP, TNF-α, and MMP-9 is crucial for understanding AD pathogenesis.

Purpose of the Study:

  • To evaluate the relationship between specific inflammatory markers and aortic dissection.
  • To compare marker levels in acute AD, chronic AD, hypertension, and healthy controls.

Main Methods:

  • Plasma concentrations of IL-6, TNF-α, MMP-9, and CRP were measured.
  • The study included 64 acute AD patients, 42 chronic AD patients, 98 hypertension patients, and 96 healthy controls.

Main Results:

  • Acute AD patients showed higher IL-6 and CRP levels compared to controls and hypertension groups.
  • MMP-9 levels were elevated in acute AD, chronic AD, and hypertension groups versus healthy controls.
  • MMP-9 was higher in non-survivors of acute AD. TNF-α correlated with time after onset in acute AD, while CRP decreased over time.

Conclusions:

  • Elevated plasma inflammatory markers are significantly associated with aortic dissection.
  • These findings reinforce the link between inflammation and AD, potentially aiding in diagnosis and risk stratification.
Abstract

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