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EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: May 28, 2026

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

Primary immunodeficiency modeling with induced pluripotent stem cells.

Itai M Pessach¹, Luigi D Notarangelo

¹Department of Pediatric Critical Care, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel. Itai.Pessach@sheba.health.gov.il

Current Opinion in Allergy and Clinical Immunology

|October 18, 2011

Summary

This summary is machine-generated.

Patient-derived induced pluripotent stem cells (iPSCs) offer a novel approach to studying primary immunodeficiencies (PIDs). This technology may overcome limitations of traditional methods and aid in developing new treatments.

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Area of Science:

Immunology
Stem Cell Biology
Genetics

Background:

Primary immunodeficiencies (PIDs) are traditionally studied using animal models, in-vitro assays, and patient tissue.
These methods have limitations, particularly in accessing disease-specific tissues.

Purpose of the Study:

To explore the use of patient-derived induced pluripotent stem cells (iPSCs) as a novel approach for studying PIDs.
To overcome limitations associated with classical PID research methods.

Main Methods:

Utilizing patient-derived induced pluripotent stem cells (iPSCs) for disease modeling.
Investigating the potential of iPSCs in understanding PID pathophysiology.

Main Results:

Recent advances enable iPSC-based disease modeling in various fields, including PIDs.
Challenges remain in the translational application of iPSCs for disease modeling and cell therapy.

Conclusions:

Patient-derived iPSCs show promise for characterizing PID pathophysiology and developing new treatments.
This technology facilitates detailed study of disease mechanisms in extra-immune tissues with reduced patient risk and complexity.