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Boron-based drugs as antiprotozoals
Robert T Jacobs1, Jacob J Plattner, Martine Keenan
1SCYNEXIS Inc., Research Triangle Park, North Carolina, USA. bob.jacobs@scynexis.com
Current Opinion in Infectious Diseases
|October 18, 2011
Summary
Boron-based benzoxaboroles show promise as new treatments for neglected tropical diseases like malaria and Chagas disease. Their unique properties and favorable pharmacokinetics support potential clinical development.
Area of Science:
- Medicinal Chemistry
- Drug Discovery
- Parasitology
Background:
- Boron-based molecules, specifically benzoxaboroles, are emerging as a promising class of therapeutic agents.
- These compounds have demonstrated activity against various protozoan parasites responsible for neglected tropical diseases.
Purpose of the Study:
- To review recent advancements in the development of boron-based drugs, particularly benzoxaboroles.
- To highlight their potential as treatments for human African trypanosomiasis, malaria, and Chagas disease.
Main Methods:
- Review of scientific literature and research from biotechnology companies.
- Analysis of the properties and activities of benzoxaborole compounds.
Main Results:
- Benzoxaboroles have shown significant potential in preclinical studies for treating neglected tropical diseases.
- Their development is supported by earlier findings of antifungal, antibacterial, and anti-inflammatory activities.
Conclusions:
- Boron's unique chemical properties, enabling reversible target interaction, are key to the efficacy of these drug candidates.
- The favorable physicochemical and pharmacokinetic profiles of benzoxaboroles suggest suitability for oral administration, metabolic stability, and low toxicity, paving the way for clinical trials.
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