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Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

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Light Spot-Based Assay for Analysis of Drosophila Larval Phototaxis
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Phase sensitive SPR sensor for wide dynamic range detection.

Y H Huang1, H P Ho, S Y Wu

  • 1Department of Electronic Engineering, the Chinese University of Hong Kong, Shatin, Hong Kong.

Optics Letters
|October 18, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a novel surface plasmon resonance (SPR) sensor design. It combines phase detection and angular interrogation to achieve both high sensitivity and a wide dynamic range for enhanced sensing applications.

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Area of Science:

  • Optoelectronics
  • Nanotechnology
  • Chemical Sensing

Background:

  • Phase detection enhances surface plasmon resonance (SPR) sensor sensitivity.
  • Phase-sensitive SPR sensors suffer from a limited dynamic range, restricting their applications.
  • Angular interrogation is a method for analyzing SPR shifts.

Purpose of the Study:

  • To develop a surface plasmon resonance (SPR) sensor with both high sensitivity and a wide dynamic range.
  • To overcome the limitations of traditional phase-sensitive SPR sensors.
  • To offer adjustable sensitivity and dynamic range in SPR sensing.

Main Methods:

  • Combining phase detection with angular interrogation in an SPR sensor design.
  • Experimental validation of the proposed SPR sensor configuration.
  • Characterization of sensor performance, including resolution and dynamic range.

Main Results:

  • Achieved a high resolution of 2.2×10-7 refractive index units (RIU).
  • Demonstrated a wide dynamic range exceeding 0.06 refractive index units (RIU).
  • Simultaneously achieved high sensitivity and a broad dynamic range.

Conclusions:

  • The proposed SPR sensor design effectively integrates phase detection and angular interrogation.
  • This approach overcomes the dynamic range limitations of conventional phase-sensitive SPR sensors.
  • The sensor offers tunable sensitivity and dynamic range, enhancing its applicability.