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Resolution of protected silaproline for a gram scale preparation
C Martin1, N Vanthuyne, H Miramon
1IBMM, UMR-CNRS-5247, Universités Montpellier I and II, Place Eugène Bataillon, Montpellier 34095, France.
Amino Acids
|October 18, 2011
Abstract:
Silaproline is an analogue of proline, which exhibits similar conformational properties. Moreover, the presence of dimethylsilyl group confers to silaproline a higher lipophilicity as well as an improved resistance to biodegradation. This report describes the comparison of two routes to obtain Fmoc-(L) Sip-OH on the gram scale using chiral HPLC resolution.
