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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: May 28, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

Brentuximab Vedotin (SGN-35).

Jessica Katz1, John E Janik, Anas Younes

  • 1Department of Hematology/Oncology, Lankenau Medical Center and Lankenau Institute of Medical Research, Wynnewood, Pennsylvania, USA.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|October 18, 2011
PubMed
Summary

Brentuximab vedotin (SGN-35) shows high response rates in Hodgkin lymphoma and anaplastic large cell lymphoma. Its efficacy may stem from direct cell killing and modulation of the tumor microenvironment.

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Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Brentuximab vedotin (SGN-35) is an antibody-drug conjugate targeting CD30.
  • CD30 is expressed on Hodgkin lymphoma and anaplastic large cell lymphoma cells.

Purpose of the Study:

  • To review the biology and clinical effects of brentuximab vedotin.
  • To explore mechanisms of action beyond direct cytotoxicity.

Main Methods:

  • Review of existing clinical trial data (Phase II).
  • Analysis of the drug conjugate's biological components and proposed mechanisms.

Main Results:

  • SGN-35 demonstrated 75% response in Hodgkin lymphoma (n=102) and 87% in anaplastic large cell lymphoma (n=30).
  • Potential mechanisms include direct MMAE-induced cytotoxicity, CD30-mediated signaling, and tumor microenvironment modulation.

Conclusions:

  • Brentuximab vedotin exhibits significant clinical efficacy in CD30-positive lymphomas.
  • Multiple mechanisms, including immune modulation, contribute to its therapeutic effect.