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Identification of Hemolytic and Phospholipase Activity in Crude Extracts from Sea Anemones by Straightforward Bioassays
Published on: March 29, 2022
Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp
Pritesh Prasad1, William Aalbersberg, Klaus-D Feussner
1Institute of Applied Science, Faculty of Science, Technology and Environment, The University of the South Pacific, Laucala Campus, Suva, Fiji Islands.
Abstract:
Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 microg/mL.

