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Biomarkers and heart disease

Michelle A Albert1

  • 1Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. maalbert@partners.org

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|October 18, 2011
PubMed

Insights

This review evaluates biomarkers and surrogate endpoints for chronic disease risk, particularly cardiovascular disease. It highlights their utility in sleep research and clinical practice, offering a framework for biomarker assessment.

Area of Science:

  • Biomedical Science
  • Clinical Research
  • Cardiovascular Medicine

Background:

  • Chronic diseases, including cardiovascular disease, pose significant public health challenges.
  • Biomarkers and surrogate endpoints are crucial for assessing disease risk and treatment efficacy.
  • The Institute of Medicine (IOM) Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease has provided foundational work.

Purpose of the Study:

  • To review the evaluation of biomarkers and surrogate endpoints in chronic disease risk.
  • To focus specifically on the application and evaluation within cardiovascular disease research.
  • To illustrate the potential use of biomarkers in sleep research and clinical settings.

Main Methods:

  • Literature review and synthesis of existing research on biomarkers and surrogate endpoints.
  • Analysis of the IOM committee's framework for biomarker qualification.
  • Case study analysis of representative biomarkers in chronic disease.

Main Results:

  • Biomarkers and surrogate endpoints require rigorous evaluation for reliable use in clinical practice.
  • A structured framework aids in assessing the validity and utility of potential biomarkers.
  • Specific examples demonstrate the impact of well-qualified biomarkers on disease research and patient care.

Conclusions:

  • Effective evaluation frameworks are essential for qualifying biomarkers and surrogate endpoints.
  • Biomarkers hold significant promise for improving risk prediction and management of chronic diseases, including cardiovascular conditions.
  • Further research and standardized evaluation are needed to fully leverage biomarkers in sleep research and clinical decision-making.

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