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Portal Hypertension

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...

Hepatic Portal System

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...

Anatomy of the Circulatory System

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The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.

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Updated: May 28, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

Hemodynamic simulation for an anatomically realistic portal system.

Harvey Ho¹, Adam Bartlett, Peter Hunter

¹Bioengineering Institute, University of Auckland, New Zealand. harvey.ho@auckland.ac.nz

Medical Image Computing and Computer-Assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

|October 19, 2011

Summary

This summary is machine-generated.

This study introduces a computer model for simulating liver portal system blood flow. The model accurately predicts how portacaval shunting surgery impacts portal vein blood flow dynamics.

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Area of Science:

Medical Imaging and Simulation
Computational Fluid Dynamics
Vascular Biology

Background:

The portal system is crucial for delivering nutrients and hormones to the liver.
Understanding portal blood flow dynamics is vital for diagnosing and treating liver diseases.
Current methods for assessing portal hemodynamics have limitations.

Purpose of the Study:

To develop and validate a computational model for simulating blood flow in a patient-specific portal system.
To investigate the hemodynamic effects of portacaval shunting surgery using the developed model.

Main Methods:

Digitization of patient-specific portal system geometry from 3D CT images.
Solving 1D partial differential equations coupled with a bifurcation model to simulate blood flow.
Validation of simulation results against published ultrasonography and phase contrast MRA data.

Main Results:

The computer model successfully simulated blood flow in the patient-specific portal system.
Simulation results showed good agreement with existing clinical data.
Simulated portacaval shunting demonstrated a significant pressure gradient, leading to reduced or reversed portal vein flow, with the shunt acting as a primary flow pathway.

Conclusions:

The developed computational model provides a valuable tool for studying portal system hemodynamics.
The model can predict the impact of surgical interventions like portacaval shunting on portal blood flow.
This approach holds potential for pre-operative planning and understanding of liver vascular diseases.