Synthetic echocardiographic image sequences for cardiac inverse electro-kinematic learning

In this paper, we propose to create a rich database of synthetic time series of 3D echocardiography (US) images using simulations of a cardiac electromechanical model, in order to study the relationship between electrical disorders and kinematic patterns visible in medical images. From a real 4D sequence, a software pipeline is applied to create several synthetic sequences by combining various steps including motion tracking and segmentation. We use here this synthetic database to train a machine learning algorithm which estimates the depolarization times of each cardiac segment from invariant kinematic descriptors such as local displacements or strains. First experiments on the inverse electrokinematic learning are demonstrated on the synthetic 3D US database and are evaluated on clinical 3D US sequences from two patients with Left Bundle Branch Block.