Related Experiment Video
Updated: May 28, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Cytotoxic and antimalarial azaphilones from Chaetomium longirostre
Natcha Panthama1, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul
1Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Abstract:
Four new azaphilones named longirostrerones A-D (1-4) and three known sterols, ergosteryl palmitate, ergosterol, and ergosterol peroxide, have been isolated from ethyl acetate extract of the fungus Chaetomium longirostre. These structures were determined by 1D and 2D NMR, IR, UV, MS, and CD spectroscopy. Compounds 1-4 exhibited strong cytotoxicity against KB cancer cell lines (IC(50) 0.23-6.38 μM), while only 1 showed potent cytotoxicity against MCF7 and NCI-H187 cell lines (IC50 0.24 and 3.08 μM, respectively). In addition, 1-3 showed antimalarial activity against Plasmodium falciparum (IC50 0.62-3.73 μM).
Related Concept Videos
Anthelminthic Agents
Diversity of Protists II
Antiprotozoal Agents
Antifungal Agents
Bacterial Phylum Chlamydiae
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
