Related Experiment Video
Updated: May 28, 2026
05:21
Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri
Published on: September 12, 2025
Coagulopathy associated with dilation and evacuation for second-trimester abortion
Ido Ben-Ami1, Noga Fuchs Weizman1, David Schneider1
1Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Acta Obstetricia Et Gynecologica Scandinavica
|October 19, 2011
Summary
Coagulopathy after second-trimester abortion differs based on fetal demise versus pregnancy termination. Early bleeding in fetal demise cases indicates a more severe condition requiring close monitoring for disseminated intravascular coagulation.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Reproductive Health
Background:
- Surgical abortion in the second trimester can lead to coagulopathy.
- Understanding the clinical and laboratory features of this complication is crucial.
Purpose of the Study:
- To characterize coagulopathy following second-trimester surgical abortions.
- To differentiate features based on indication for abortion (fetal demise vs. pregnancy termination).
Main Methods:
- Retrospective study of 1249 women undergoing late second-trimester surgical abortions.
- Comparison of 20 women with coagulopathy, divided into fetal demise (n=14) and pregnancy termination (n=6) groups.
- Analysis of gestational age, indication, clotting tests, and blood product administration.
Main Results:
- Women undergoing termination bled significantly earlier than those with fetal demise.
- Gradual deterioration of clotting tests was more common in the fetal demise group.
- Early bleeding in fetal demise cases correlated with a more severe clinical presentation.
Conclusions:
- Coagulopathy following surgical abortion presents differently depending on whether it's for fetal demise or termination.
- Pathophysiology likely differs between these groups.
- Women with fetal demise and bleeding require careful monitoring for potential disseminated intravascular coagulation (DIC).
Related Concept Videos
01:22Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:21Cytotoxic Edema: Pathophysiology
Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...