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Related Experiment Video

Updated: May 28, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Air elimination capability in rapid infusion systems.

N Zoremba¹, C Gruenewald, M Zoremba

¹Department of Anaesthesiology, University Hospital RWTH Aachen, Aachen, Germany. nzoremba@ukaachen.de

|October 19, 2011

Summary

Pressure infusion devices showed good air elimination, but higher flows increased uneliminated air. Ultrasonic air detection offers significant safety improvements against air embolism during rapid infusions.

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Area of Science:

Medical Devices
Anesthesiology
Critical Care Medicine

Background:

Pressure infusion devices deliver large fluid volumes rapidly in clinical settings.
Air infusion is a significant complication, yet current devices have limited air detection and removal capabilities.
Preventing air embolism is crucial during high-volume fluid resuscitation.

Purpose of the Study:

To evaluate the air elimination performance of three pressure infusion devices: Fluido®, Level 1®, and Ranger®.
To assess the impact of varying infusion flow rates and air volumes on air elimination efficiency.
To determine the safety and efficacy of these devices in preventing air embolism.

Main Methods:

Tested Fluido®, Level 1®, and Ranger® pressure infusion devices with crystalloid solutions.
Infusion flow rates varied from 100 to 800 ml/min.
Air was introduced via bolus injection (25-200 ml) or continuous infusion, with perfusate collected to measure eliminated air.

Main Results:

All tested devices demonstrated good overall air elimination capabilities.
A negligible volume of delivered air was detected, insufficient to cause significant air embolism.
Higher infusion flow rates resulted in a greater amount of uneliminated air across all devices compared to lower flows.

Conclusions:

The tested pressure infusion devices possess effective air elimination capabilities.
Ultrasonic air detection with automatic shutoff significantly enhances safety, reliably preventing air embolism, especially at rapid flow rates.
While generally effective, increased vigilance for uneliminated air is advised during high-flow infusions.