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Updated: May 28, 2026
An In Vitro Assay to Detect tRNA-Isopentenyl Transferase Activity
Published on: October 8, 2018
Antiproliferative activity of N(6)-isopentenyladenosine on HCT-15 colon carcinoma cell line
Mehdi Rajabi1, Jamshid Mehrzad, Elena Gorincioi
1Department of Chemistry and Biochemistry, Islamic Azad University , Neyshabur Branch, Neyshabur, Iran. m.rajabi.s@gmail.com
Abstract:
N(6)-Isopentenyladenosine (iPA), a member of the cytokinin family of plant hormones, exerts remarkable inhibition on tumor cell proliferation and apoptosis in several tumor cell lines. In this study, we report that iPA is able to inhibit the proliferation and promotes apoptosis in HCT-15 human colon cancer cells in a dose-dependent manner with a concentration of 2.5 μM, which causes 50% inhibition of cell viability. The cell cycle analysis by flow cytometry showed that iPA-induced growth arrest could be associated to apoptosis. Moreover, suppression of clonogenic activity occurs after exposure to iPA at a concentration of 2.5 μM for HCT-15.
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