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[Intravitreal triamcinolone acetonide use in diffuse persistent diabetic macular edema]
M García Fernández1, A García Alonso, M Fonollá Gil
1Sección de Retina, Servicio de Oftalmología, Hospital Universitario Central de Asturias (H.U.C.A), Oviedo, Asturias. migarci@hotmail.es
Archivos De La Sociedad Espanola De Oftalmologia
|October 19, 2011
Summary
Intravitreal triamcinolone injections (iv TA) improved vision and reduced macular thickness in persistent diabetic macular edema (DMO). Caution is advised due to transient effects and potential adverse events in selected cases.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Context:
- Diabetic macular edema (DMO) is a leading cause of vision loss in diabetic patients.
- Persistent DMO poses significant challenges for effective treatment.
- Intravitreal injections are a common therapeutic approach for retinal conditions.
Purpose:
- To evaluate the efficacy of intravitreal triamcinolone acetonide (iv TA) injections for persistent diffuse diabetic macular edema (DMO).
- To assess changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT) via optical coherence tomography (OCT).
- To analyze the safety profile of iv TA, including intraocular pressure (IOP) and cataract progression.
Summary:
- A retrospective study included 16 patients (22 eyes) with persistent DMO treated with iv TA.
- Improvements in BCVA were observed at 1, 3, and 6 months (P<.05 at 3 months).
- Increased IOP and cataract progression were noted side effects, while no endophthalmitis occurred.
Impact:
- Intravitreal TA demonstrates short-term efficacy in improving BCVA and reducing CMT in persistent DMO.
- Over 70% clinical resolution was achieved, suggesting therapeutic potential.
- Careful selection of refractory cases is recommended due to the transient nature and potential adverse effects of iv TA.
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