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Eupatorium perfoliatum L.: phytochemistry, traditional use and current applications
Andreas Hensel1, Mareike Maas, Jandirk Sendker
1University of Münster, Institute for Pharmaceutical Biology and Phytochemistry, Münster, Germany. ahensel@uni-muenster.de
Journal of Ethnopharmacology
|October 19, 2011
Summary
Eupatorium perfoliatum, or common boneset, shows anti-inflammatory and antiplasmodial effects in preclinical studies, supporting its traditional use for colds and inflammatory conditions. Further research is needed to confirm immunostimulating properties and establish quality control methods.
Area of Science:
- Phytochemistry
- Ethnobotany
- Pharmacology
Background:
- Eupatorium perfoliatum L. (common boneset) has a history of use by North American indigenous peoples and in Europe for fever and colds.
- Extracts are utilized for their purported immunostimulating properties.
Purpose of the Study:
- To review published data on the phytochemistry, ethnopharmacological use, and clinical/preclinical evidence of Eupatorium perfoliatum.
- To evaluate the scientific basis for its traditional applications.
Main Methods:
- A literature survey was conducted using SciFinder and ethnopharmacological literature from university libraries.
- Systematic research was performed on published papers and patents.
Main Results:
- Detailed phytochemical analysis reveals volatile oil, caffeic acid derivatives, flavonoids, sesquiterpene lactones, tannins, and polysaccharides.
- Preclinical studies demonstrate anti-inflammatory effects of ethanolic extracts, linked to eupafolin and sesquiterpene lactones.
- Evidence suggests antiplasmodial, antioxidative, and immunomodulating activities; clinical data indicate positive trends for common cold treatment.
Conclusions:
- While immunostimulating properties lack in vitro confirmation, Eupatorium perfoliatum extracts exhibit anti-inflammatory and antiplasmodial effects.
- These findings support the traditional use for conditions like the common cold, rheumatism, and arthritis.
- Establishing modern pharmacopoeial control methods is crucial for ensuring consistent herbal material quality.
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