AGC kinases in plant development and defense
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Updated: May 28, 2026

Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
Heribert Hirt1, Ana V Garcia, Ralf Oelmüller
1URGV Plant Genomics, INRA-CNRS-University of Evry, Evry, France.
Abstract:
More than 100,000 publications demonstrate that AGC kinases are important regulators of growth, metabolism, proliferation, cell divison, survival and apoptosis in mammalian systems. Mutation and/or dysregulation of these kinases contribute to the pathogenesis of many human diseases, including cancer and diabetes. Although AGC kinases are also present in plants, little is known about their functions. We demonstrated that the AGC kinase OXIDATIVE SIGNAL-INDUCIBLE 1 (OXI1/AGC2-1) regulate important developmental processes and defense responses in plants. The summary of recent progress also demonstrates that we are only beginning to understand the role of this kinase pathway in plants.
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