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Ambulatory blood pressure variability is associated with restenosis after percutaneous coronary intervention in

Serkan Cay1, Goksel Cagirci, Ahmet Duran Demir

  • 1Department of Cardiology, Gulhane Military Medical Academy Haydarpasa Education Hospital, Istanbul, Turkey. cayserkan@yahoo.com

Atherosclerosis
|October 19, 2011
PubMed

Insights

Blood pressure variability is linked to restenosis after percutaneous coronary intervention (PCI). Higher BP variability indices predict restenosis, offering sensitive and specific diagnostic markers.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Clinical Trials

Background:

  • Blood pressure (BP) variability is a known risk factor for cardiovascular events.
  • Limited data exist on the association between BP variability and binary restenosis following percutaneous coronary intervention (PCI).

Purpose of the Study:

  • To investigate the relationship between BP variability and binary restenosis after PCI.
  • To determine if BP variability indices can predict restenosis post-PCI.

Main Methods:

  • A multicenter study involving 100 stable coronary artery disease patients undergoing PCI.
  • 24-hour ambulatory BP monitoring was performed before PCI to calculate BP variability indices (SD, VC).
  • Patients were assessed for binary restenosis via coronary angiography at 6 months, forming restenosis (n=30) and control (n=70) groups.

Main Results:

  • Significantly higher systolic and diastolic BP variability indices (24-h, day, night) were observed in the restenosis group compared to the control group.
  • All BP variability indices, except diastolic VC at night, were independent predictors of restenosis in multivariate analysis.
  • Cut-off values for 24-h systolic SD (11.4mmHg) and VC (13%) demonstrated high sensitivity (93%) and specificity (94% and 91%) for predicting binary restenosis.

Conclusions:

  • Blood pressure variability indices are significantly associated with binary restenosis after PCI.
  • Elevated BP variability independently predicts restenosis, serving as a sensitive and specific marker for risk stratification.
Abstract

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