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Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...

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Sexually dimorphic gene expression in non-human primate ESCs analyzed stringently.

Dorit Shweiki¹, Ahmi Ben-Yehudah, Carrie Redinger

¹Bioinformatics Program, School of Computer Science, The Academic College of Tel Aviv-Yaffo, Tel Aviv, Israel. dorits@mta.ac.il

Biochemical and Biophysical Research Communications

|October 19, 2011

Summary

Researchers identified sexually dimorphic gene expression in non-human primate embryonic stem cells (nhpESCs). This study enhances understanding of early developmental processes contributing to sexual dimorphism in humans.

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Area of Science:

Developmental Biology
Genetics
Stem Cell Research

Background:

Sexual dimorphism is evident in humans from early development through adulthood.
Understanding the genetic basis of early sexual dimorphism is crucial for developmental biology.

Purpose of the Study:

To investigate sexually dimorphic gene expression in non-human primate embryonic stem cells (nhpESCs).
To identify genes contributing to early sexual dimorphism and compare findings with human embryonic stem cell (hESC) data.

Main Methods:

Stringent analysis of gene expression in pedigreed nhpESCs using location-specific probes to avoid cross-reactivity.
Verification of identified sexually dimorphic transcripts using real-time quantitative PCR (q-PCR).
Comparison of nhpESC findings with available human ESC datasets.

Main Results:

Seventeen sexually dimorphic transcripts, representing 15 genes (9 autosomal), were identified in nhpESCs.
Five of these transcripts were validated via real-time q-PCR.
Three human X-linked genes exhibited sexual dimorphism when compared to nhpESC data.

Conclusions:

The study identified novel sexually dimorphic gene expression in early development using nhpESCs.
Findings suggest conserved mechanisms of sexual dimorphism between non-human primates and humans, particularly on the X chromosome.
This research deepens the understanding of the genetic underpinnings of early sexual differentiation.