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Dengue-associated transient muscle dysfunction: clinical, electromyography and histopathological changes.
U K Misra1, J Kalita, P K Maurya
1Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. drukmisra@rediffmail.com
Infection
|October 19, 2011
Summary
Dengue virus infection frequently causes temporary muscle dysfunction, affecting both clinical and subclinical presentations. Muscle weakness in dengue patients is often transient and resolves within two weeks of treatment.
Area of Science:
- Neurology
- Infectious Diseases
- Musculoskeletal System
Background:
- Dengue virus infection is known to cause myalgia, but detailed studies on muscle involvement are limited.
- Understanding the frequency, severity, and underlying mechanisms of dengue-associated muscle dysfunction is crucial.
Purpose of the Study:
- To investigate the clinical, electromyographic, and histological manifestations of muscle dysfunction in dengue patients.
- To characterize the spectrum of muscle involvement, from subclinical to severe weakness.
Main Methods:
- A cohort of dengue-positive patients admitted to a neurology ward was studied.
- Clinical examinations, neurological assessments, blood tests (including creatine kinase), electromyography (EMG), and muscle biopsies were performed.
Main Results:
- 31 out of 39 dengue patients exhibited muscle involvement, with 16 showing clinical symptoms.
- Muscle weakness correlated with lower platelet counts and elevated creatine kinase (CK) levels.
- Electromyography showed specific motor unit potential changes, and muscle biopsies revealed interstitial hemorrhage and occasional necrosis.
Conclusions:
- Dengue commonly leads to benign and self-limiting muscle dysfunction.
- The muscle involvement associated with dengue is typically transient and resolves with treatment.
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