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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...

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Related Experiment Video

Updated: May 28, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

[The platelet and its challenges].

S Petros1, L Weidhase, M Neef

  • 1Internistische Intensivstation, Universitätsklinikum Leipzig AöR, Liebigstrasse 20, Leipzig, Germany. sirak.petros@medizin.uni-leipzig.de

Medizinische Klinik, Intensivmedizin Und Notfallmedizin
|October 19, 2011
PubMed
Summary
This summary is machine-generated.

Thrombocytopenia in intensive care is common and linked to higher mortality. Correct diagnosis is crucial to avoid patient harm from misdiagnosis and incorrect treatment.

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Last Updated: May 28, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

Area of Science:

  • Critical care medicine
  • Hematology
  • Pathophysiology

Background:

  • Thrombocytopenia, a low platelet count, is a frequent complication in intensive care units (ICUs).
  • It is strongly associated with increased patient mortality and morbidity.
  • The etiology of thrombocytopenia in ICUs is complex and multifactorial.

Observation:

  • This case report highlights a patient presenting with thrombocytopenia in an intensive care setting.
  • Multiple potential causes for the low platelet count were considered simultaneously.
  • Accurate etiological correlation proved challenging due to overlapping conditions.

Findings:

  • The case underscores the difficulty in pinpointing a single cause of thrombocytopenia when several conditions coexist.
  • Misdiagnosis can arise from overlooking the complex interplay of pathophysiological factors.
  • Inappropriate management strategies may result from an incomplete diagnostic assessment.

Implications:

  • Accurate pathophysiological and clinical evaluation is essential for managing thrombocytopenia in critical care.
  • Avoiding misdiagnosis prevents unnecessary interventions and optimizes patient care pathways.
  • This case emphasizes the need for a thorough diagnostic approach in complex critical care scenarios.