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Updated: Aug 18, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
Experimental models of autoimmune diseases
1Pathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France.
Abstract:
Several experimental models of autoimmune diseases have been studied which often mimic the human situation. Autoreactive T cells that emerge either spontaneously or after immunization have been identified in several situations. The main lesson from these models is that these autoreactive T cells are negatively controlled in the normal situation and that a defect either inherited or acquired in this regulatory circuit is responsible for autoimmunity.
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