Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Inflammatory Stress Response During Pregnancy as a Connecting Link in Intergenerational Risk Cascades.

Developmental psychobiology·2026
Same author

Detection of Posttraumatic Stress Disorder With Rest-Activity Data: Machine Learning Approach Using Wearable and Self-Report Data.

JMIR formative research·2026
Same author

Classifying Severity of Interpersonal Violence in Sport: A Scoping Review.

Trauma, violence & abuse·2026
Same author

Nonconsensual sexual behavior among youth: Age dynamics and implications for prevention.

Child abuse & neglect·2026
Same author

Trauma, Stress, and Reproductive Health: A Bio-Psycho-Social Perspective on Violence Exposure in Immigrant Women.

Research in nursing & health·2026
Same author

Online Recruitment of Young People for Research on Problematic Sexual Behavior.

Journal of child sexual abuse·2026

Related Experiment Video

Updated: May 28, 2026

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

Do infants show a cortisol awakening response?

Melissa A Bright1, Douglas A Granger, Janet E Frick

  • 1Department of Psychology, University of Georgia, Athens, GA 30602, USA. mbright@uga.edu

Developmental Psychobiology
|October 19, 2011
PubMed
Summary

The cortisol awakening response (CAR) differs in infants compared to adults. Infant cortisol levels decreased after waking, unlike the typical adult CAR increase.

Area of Science:

  • Endocrinology
  • Developmental Psychology
  • Neuroscience

Background:

  • The cortisol awakening response (CAR) is a well-documented phenomenon in adults, reflecting hypothalamic-pituitary-adrenal axis activity upon waking.
  • Previous research has primarily focused on the CAR in adult populations, with limited understanding in infants.

Purpose of the Study:

  • To investigate the cortisol awakening response (CAR) in infants for the first time.
  • To compare infant CAR patterns with established adult CAR responses.

Main Methods:

  • Saliva samples were collected from 32 mothers and their infants (aged 7.8–17.4 months) upon waking and 30 minutes later.
  • Cortisol levels were measured following morning waking and the infant's first nap.

Main Results:

More Related Videos

Measuring Cardiac Autonomic Nervous System (ANS) Activity in Toddlers - Resting and Developmental Challenges
08:22

Measuring Cardiac Autonomic Nervous System (ANS) Activity in Toddlers - Resting and Developmental Challenges

Published on: February 25, 2016

Cortisol Measurement in Koala (Phascolarctos cinereus) Fur
09:11

Cortisol Measurement in Koala (Phascolarctos cinereus) Fur

Published on: August 23, 2019

Related Experiment Videos

Last Updated: May 28, 2026

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

Measuring Cardiac Autonomic Nervous System (ANS) Activity in Toddlers - Resting and Developmental Challenges
08:22

Measuring Cardiac Autonomic Nervous System (ANS) Activity in Toddlers - Resting and Developmental Challenges

Published on: February 25, 2016

Cortisol Measurement in Koala (Phascolarctos cinereus) Fur
09:11

Cortisol Measurement in Koala (Phascolarctos cinereus) Fur

Published on: August 23, 2019

  • Infant cortisol levels showed a decline from waking to 30 minutes post-waking, contrasting with the adult CAR.
  • No significant cortisol changes were observed following infant naps.
  • Mother-infant cortisol levels were associated at both group and dyadic levels.

Conclusions:

  • The cortisol awakening response (CAR) in infants appears distinct from that observed in adults.
  • Infant sleep-wake cycles and associated hormonal responses warrant further investigation.
  • Maternal and infant cortisol levels exhibit interconnectedness.