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Updated: May 28, 2026
Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
Published on: November 19, 2020
Direct measurement of tissue blood flow and metabolism with diffuse optics
Rickson C Mesquita1, Turgut Durduran, Guoqiang Yu
1Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA. rickson@sas.upenn.edu
Abstract:
Diffuse optics has proven useful for quantitative assessment of tissue oxy- and deoxyhaemoglobin concentrations and, more recently, for measurement of microvascular blood flow. In this paper, we focus on the flow monitoring technique: diffuse correlation spectroscopy (DCS). Representative clinical and pre-clinical studies from our laboratory illustrate the potential of DCS. Validation of DCS blood flow indices in human brain and muscle is presented. Comparison of DCS with arterial spin-labelled MRI, xenon-CT and Doppler ultrasound shows good agreement (0.50
