Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein kinase C in transmembrane signalling.

A Farago1, Y Nishizuka

  • 11st Institute of Biochemistry, Semmelweis University Medical School, Budapest, Hungary.

FEBS Letters
|August 1, 1990
PubMed
Summary

Protein kinase C (PKC) is a crucial enzyme family involved in cell signaling. Different PKC members regulate diverse cellular functions, including membrane processes and gene activation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What hides behind the MASC: clinical response and acquired resistance to entrectinib after ETV6-NTRK3 identification in a mammary analogue secretory carcinoma (MASC).

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

[Role of fats in oxidation in living organisms, with special reference to coenzyme O].

[Kagaku] [Science]·2014
Same author

The phosphorylation site of Ca(2+)-dependent protein kinase from alfalfa.

Plant molecular biology·2013
Same author

Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

The protein kinase C family and lipid mediators for transmembrane signaling and cell regulation.

Alcoholism, clinical and experimental research·2001
Same author

Protein kinase C decreases the hepatocyte growth factor-induced activation of Erk1/Erk2 MAP kinases.

Cellular signalling·2000

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Molecular Signaling

Background:

  • Protein kinase C (PKC) acts as a second messenger transducer for diacylglycerol.
  • PKC is a major receptor for tumor-promoting phorbol esters.
  • PKC comprises a family of proteins with distinct structures and properties.

Purpose of the Study:

  • To elucidate the diverse roles of Protein Kinase C (PKC) family members.
  • To understand the distribution and localization of PKC isoforms across different organisms and tissues.
  • To explore the involvement of PKC in cellular signaling pathways and responses.

Main Methods:

  • Enzyme characterization
  • Subcellular localization studies
  • Analysis of signaling pathway interactions

Main Results:

  • PKC family members exhibit distinct structural and enzymatic characteristics.
  • Isoforms show differential distribution in cell types and intracellular locations.
  • PKC interacts with multiple signaling pathways, modulating cellular responses.

Conclusions:

  • Each PKC member plays specific roles in cellular functions.
  • PKC is critical for regulating membrane functions.
  • PKC activation is involved in the control of gene transcription.

Related Experiment Videos