Related Experiment Video
Updated: May 28, 2026

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material
Published on: December 20, 2024
In vivo disintegration of four different luting agents.
Deniz Gemalmaz1, Cornelis H Pameijer, Mark Latta
1Department of Prosthetic Dentistry, School of Dentistry, Marmara University, 34726 Istanbul, Turkey.
Zinc phosphate cement showed the most disintegration in vivo, unlike glass ionomer and resin cements. Intraoral erosion behavior of glass ionomer cement matched resin-based cements, differing from lab findings.
Area of Science:
- Dental Materials Science
- Biomaterials Engineering
- Clinical Dentistry
Background:
- Luting agents are crucial for dental restorations.
- Understanding their long-term intraoral stability is essential.
- Previous studies often rely on laboratory conditions, which may not reflect clinical reality.
Purpose of the Study:
- To evaluate the in vivo disintegration of four luting agents.
- To compare the intraoral erosion of zinc phosphate, glass ionomer, resin-modified glass ionomer, and resin cements.
- To assess the influence of time on luting agent degradation under clinical conditions.
Main Methods:
- An intraoral sample holder was used in 12 patients.
- Four luting agents (zinc phosphate, glass ionomer, resin-modified glass ionomer, resin cement) were tested.
- Epoxy replicas were made from impressions taken over 18 months and scanned to calculate volume loss.
Main Results:
- Zinc phosphate cement exhibited the highest mean volume loss.
- Glass ionomer, resin-modified glass ionomer, and resin cements showed similar, significantly lower volume loss compared to zinc phosphate.
- Both cement type and duration significantly impacted volume loss (P < 0.001).
Conclusions:
- Zinc phosphate cement demonstrates the least intraoral stability among the tested luting agents.
- Glass ionomer and resin-based cements exhibit comparable in vivo disintegration.
- Intraoral conditions lead to erosion behavior in glass ionomer cements similar to resin-based cements, contrasting with laboratory findings.
Related Concept Videos
In Vitro Drug Dissolution: Alternative Methods
In Vitro Drug Dissolution: Compendial Testing Models II
In Vitro Drug Dissolution: Compendial Testing Models I
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...