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Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study.
Kameshwar Prasad1, Amit Kumar, Jitendra Kumar Sahu
1Department of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Stroke Research and Treatment
|October 19, 2011
Summary
Granulocyte colony-stimulating factor (G-CSF) shows potential safety and feasibility for acute ischemic stroke patients. Further large-scale studies are needed to confirm its efficacy in stroke recovery.
Area of Science:
- Neurology
- Hematology
- Clinical Research
Background:
- Emerging evidence suggests granulocyte colony-stimulating factor (G-CSF) may benefit acute ischemic stroke patients.
- G-CSF is a therapy that stimulates the production of granulocytes, a type of white blood cell.
Purpose of the Study:
- To explore the feasibility, safety, and preliminary efficacy of G-CSF therapy in patients experiencing acute ischemic stroke.
- To assess the impact of G-CSF on functional outcomes in stroke survivors.
Main Methods:
- A randomized study involving 10 patients with acute ischemic stroke, allocated in a 1:1 ratio.
- Intervention group received 10 μg/kg G-CSF subcutaneously daily for five days alongside conventional care.
- Control group received conventional treatment alone. Efficacy was measured using Barthel Index (BI), National Institute of Health Stroke Scale, and modified Rankin Scale at baseline, one month, and six months.
Main Results:
- One patient in the G-CSF arm died from raised intracranial pressure; no other severe adverse events were reported.
- No statistically significant differences in outcome scores were observed between the G-CSF and control groups.
- A trend towards higher improvement in the Barthel Index (BI) was noted in the G-CSF intervention group.
Conclusions:
- This study provides preliminary evidence for the safety, feasibility, and tolerability of G-CSF therapy in acute ischemic stroke.
- The study lacked sufficient power to definitively assess efficacy.
- Larger sample size studies are required to confirm these preliminary findings and explore G-CSF's therapeutic potential in stroke.
