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Updated: May 28, 2026

An Ex vivo Culture System to Study Thyroid Development
Published on: June 6, 2014
[Expression of CCR1 in the orbital fibroblasts with thyroid associated ophthalmopathy]
Chun-Ling Liu1, Xue-Jin Zhang, Bo Guo
1Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the expression of chemokine receptor (CCR1) in the orbital fibroblasts (OFs) with thyroid associated ophthalmopathy (TAO) and to explore the pathogenesis of TAO.
Methods:
By immunohistochemistry, the expression of CCR1 was studied in 25 cases of TAO patients and 10 normal control subjects and the correlation between CCR1 and GAS was analysed.
Results:
The expression of CCR1 in the OFs with TAO was positive, but it was negative or weak positive in normal control subjects. The difference between them was significant (P < 0.05). And the expression of CCR1 in the OFs with TAO had no significant correlation with GAS (r = 0. 048, P > 0.05).
Conclusion:
The expression of chemokine receptor CCR1 is higher on OFs of TAO patients than that of normal subjects. CCR1 maybe play a role in pathogenesis of TAO.
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