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Updated: May 28, 2026
06:46
Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
Published on: January 16, 2013
[The relationship between anaphylatoxin C3a and benign prostatic hyperplasia with inflammation]
Liang Xie1, Shu-Lin Cheng, Yi-Zhu Li
1Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
Summary
Anaphylatoxin C3a levels in expressed prostatic secretions (EPS) can diagnose prostate inflammation in benign prostatic hyperplasia (BPH) patients. High C3a levels correlate with inflammation severity and NIH-CPSI scores.
Area of Science:
- Urology
- Immunology
- Pathology
Context:
- Benign prostatic hyperplasia (BPH) is a common condition in aging men.
- Prostate inflammation is frequently observed in BPH patients.
- Diagnosing prostate inflammation can be challenging.
Purpose:
- To investigate the relationship between anaphylatoxin C3a levels in expressed prostatic secretions (EPS) and prostate tissue inflammation in BPH patients.
- To evaluate C3a as a diagnostic marker for inflammation in BPH.
Summary:
- This study analyzed 40 BPH patients undergoing TURP and 10 healthy controls.
- C3a levels in EPS were significantly higher in BPH patients with inflammation compared to controls.
- EPS C3a demonstrated high sensitivity (0.97) and specificity (0.70) for detecting BPH-associated inflammation.
- C3a levels correlated with NIH-CPSI scores but not with PSA, age, BMI, prostate volume, or urine WBC.
Impact:
- Anaphylatoxin C3a in EPS serves as a valuable biomarker for diagnosing prostatic histological inflammation in BPH.
- This finding may lead to improved diagnostic strategies for BPH complications.
- Further research can explore therapeutic interventions targeting C3a pathways in BPH.
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