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[Protective effect of hydroxysafflor yellow A on endothelial cell injury induced by lipopolysaccharide]
Xiaofei Wang1, Baoxia Zang, Wei Wu
1Department of Pharmacology, Beijing Institute of Heart Lung and Blood Vessel Diseases-Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. wangxiaofei610@sina.com
Abstract:
To observe the protective effect of hydroxyl safflor yellow A (HSYA) on endothelial cell (EC). It has been observed by RT-PCR that HSYA can inhibit the elevation of TNF-alpha, IL-6, ICAM-1 and VCAM-1 mRNA level induced by LPS. The result of immunofluorescence test suggested that HSYA can alleviate p65 subgroup of NF-kappaB nuclear translocation. The experiment on EA-HY926 cell line proved that HSYA can protect EC against inflammation injury.