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Updated: May 28, 2026
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis of novel spin-labelled combretastatin A-4 derivatives as potential antineoplastic agents
Xiao-Jing Li1, Liu Yang, Ying-Qian Liu
1School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China.
Abstract:
Four novel spin-labelled combretastatin A-4 (CA-4) analogues were first synthesised in quantitative yield by reacting CA-4 with the corresponding nitroxyl radical. Their cytotoxic activities against A-549 (human lung cancer) and HePG-2 (human liver cancer) in vitro were evaluated, and the results indicated that these derivatives were more cytotoxic than the clinical drug irinotecan.
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