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Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

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[Circulating citrulline levels: a biomarker for intestinal functionality assessment].

Pascal Crenn¹, Mouna Hanachi, Nathalie Neveux

¹Assistance publique-Hôpitaux de Paris, Hôpital Raymond-Poincaré, Université de Versailles-Saint-Quentin-en-Yvelines, Département de Médecine Aiguë Spécialisée, EA 4497, Garches, France. pascal.crenn@rpc.aphp.fr

Annales De Biologie Clinique

|October 20, 2011

Summary

Circulating citrulline is a promising biomarker for assessing intestinal function. Low plasma citrulline levels can indicate intestinal failure and guide parenteral nutrition decisions.

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Area of Science:

Biochemistry
Gastroenterology
Clinical Biomarkers

Context:

Plasma citrulline is synthesized by intestinal enterocytes.
It serves as a precursor for arginine production in the kidneys.
Citrulline is not incorporated into proteins or nutritional products.

Purpose:

To highlight circulating citrulline as an innovative biomarker candidate for intestinal function assessment.
To establish plasma citrulline as a biomarker for enterocyte functional metabolic mass (trophicity).
To define its utility in various intestinal diseases and guide parenteral nutrition.

Summary:

Plasma citrulline concentration correlates with active functional small bowel remnant length.
In clinical settings, it's an established biomarker for enterocyte trophicity in children and adults.
Levels below 10 μmol/L serve as a threshold for parenteral nutrition in intestinal failure.

Impact:

Plasma citrulline offers an objective measure of intestinal function, independent of nutritional status.
Regular monitoring aids in managing intestinal diseases like short bowel syndrome and chemotherapy-induced enteropathy.
Its utility is significant, except in cases of severe renal failure.