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Fluorescence Lifetime Macro Imager for Biomedical Applications

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Published on: April 7, 2023

Upconversion nanophosphors for small-animal imaging.

Jing Zhou¹, Zhuang Liu, Fuyou Li

¹Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, PR China.

Chemical Society Reviews

|October 20, 2011

Summary

This summary is machine-generated.

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Rare-earth upconversion nanophosphors (UCNPs) offer advanced small-animal bioimaging due to unique luminescence. This review covers UCNP synthesis, modification, and applications in targeted imaging and therapy.

Area of Science:

Nanotechnology
Materials Science
Biomedical Imaging

Background:

Rare-earth upconversion nanophosphors (UCNPs) emit high-energy light when excited by near-infrared light.
Their unique luminescence offers advantages like no auto-fluorescence and deep tissue penetration.
UCNPs are emerging as powerful tools for small-animal imaging.

Purpose of the Study:

To critically review recent advancements in UCNP synthesis, surface modification, and bioconjugation.
To detail UCNP applications in various small-animal imaging modalities.
To explore UCNPs as multifunctional platforms for combined imaging and therapy.

Main Methods:

Summarization of recent literature on water-soluble UCNP synthesis.
Review of surface modification and bioconjugation strategies for UCNPs.

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Analysis of UCNP applications in tumor, lymphatic, vascular imaging, and cell tracking.

Main Results:

UCNPs demonstrate significant potential for small-animal bioimaging.
Various UCNP-based strategies enable targeted imaging and cell tracking.
UCNPs can be engineered as multifunctional carriers for theranostics.

Conclusions:

UCNPs are highly promising for advanced small-animal imaging and theranostics.
Further research into UCNP biodistribution and toxicology is essential.
Development of UCNP-based nanoplatforms presents significant opportunities.