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Related Experiment Videos

[Does induction with midazolam decrease stress response during anesthesia?].

T Nishiyama1, A Hirasaki, Y Odaka

  • 1Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu.

Masui. the Japanese Journal of Anesthesiology
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

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Journal of anesthesia·2013

Midazolam more effectively suppresses surgical stress responses than thiamylal. This study found midazolam reduced epinephrine levels post-intubation, while thiamylal increased norepinephrine, indicating better stress mitigation with midazolam.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Surgical Stress Response

Background:

  • Anesthetic induction agents play a critical role in modulating the physiological stress response during surgery.
  • Understanding the comparative effects of different induction agents on catecholamine levels is crucial for optimizing anesthetic management.

Purpose of the Study:

  • To compare the effects of midazolam and thiamylal as anesthetic induction agents on the stress response during surgery.
  • To evaluate the impact of midazolam versus thiamylal on plasma catecholamine concentrations (epinephrine and norepinephrine) in surgical patients.

Main Methods:

  • A randomized study involving 12 patients divided into two groups: midazolam and thiamylal.
  • Anesthesia was induced with midazolam (0.2 mg/kg) or thiamylal (4 mg/kg), maintained with oxygen, nitrous oxide, and enflurane.

Related Experiment Videos

  • Plasma catecholamine levels were measured at multiple time points: preinduction, and 10, 30, 60, 120, and 180 minutes post-intubation.

    • Main Results:

    • No significant overall difference in plasma catecholamine concentrations between the midazolam and thiamylal groups.
    • The midazolam group showed a significant decrease in plasma epinephrine levels 10 minutes post-intubation compared to preinduction.
    • The thiamylal group exhibited a significant increase in plasma norepinephrine levels at 120 and 180 minutes post-intubation compared to preinduction.

    Conclusions:

    • Midazolam induction appears to provide more intense suppression of the stress response during anesthetic induction and surgery compared to thiamylal.
    • Midazolam's effect on reducing epinephrine and potentially norepinephrine suggests a superior role in blunting surgical stress responses.