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Related Experiment Videos

[Free radicals in digestive diseases].

T Yoshikawa1, M Kondo

  • 1First Department of Medicine, Kyoto Prefectural University of Medicine.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|March 1, 1990
PubMed
Summary

Free radicals and active oxygen species contribute to digestive diseases by causing cell damage through lipid peroxidation. Antioxidant enzymes like superoxide dismutase and catalase show potential in treating these injuries.

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[Free radicals and diseases].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·1992

Area of Science:

  • Biochemistry
  • Cell Biology
  • Gastroenterology

Context:

  • Free radicals and active oxygen species are implicated in numerous biochemical reactions.
  • Lipid peroxidation, initiated by free radicals, is a major cause of cell membrane damage.
  • Emerging evidence links free radicals to the etiology of various digestive diseases.

Purpose:

  • To review the role of oxygen-derived free radicals in digestive system disorders.
  • To highlight the mechanisms of tissue injury mediated by reactive oxygen species.
  • To discuss the involvement of specific radicals like superoxide and hydroxyl radicals.

Summary:

  • Ischemia/reperfusion injury in the stomach, small intestine, and liver is exacerbated by free radicals.
  • Hydroxyl radical initiates lipid peroxidation, damaging cellular membranes and leading to cell death.
  • Xanthine oxidase and polymorphonuclear leukocytes (PMNs) are key sources of reactive oxygen species, with PMNs crucial in inflammatory bowel diseases.

Impact:

  • Understanding the role of free radicals is crucial for developing therapeutic strategies against digestive diseases.
  • Antioxidant treatments, such as superoxide dismutase and catalase, demonstrate potential in mitigating tissue injury.
  • This research underscores the fundamental involvement of oxygen-derived free radicals in the pathogenesis of digestive system disorders.

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