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Updated: May 28, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Hematological features in adolescents with periodontitis
Rodrigo López1, Bruno G Loos, Vibeke Baelum
1Department of Periodontology, Faculty of Health Sciences, Aarhus University, Vennelyst Boulevard 9, 8000 Aarhus C, Denmark. rlopez@odont.au.dk
Clinical Oral Investigations
|October 20, 2011
Summary
Adolescent periodontitis cases showed higher mean platelet volume than controls. While standard blood tests were normal, eosinophil counts and mean platelet volume may indicate periodontal inflammation in teens.
Area of Science:
- Oral Health
- Hematology
- Adolescent Medicine
Background:
- Periodontitis is a common oral inflammatory condition.
- Adolescent periodontitis requires understanding its unique characteristics.
- Hemogram findings in adolescent periodontitis are not well-established.
Purpose of the Study:
- To compare hemogram findings between adolescent periodontitis cases and controls.
- To investigate associations between specific periodontitis parameters and blood cell counts.
Main Methods:
- A case-control study involving 87 adolescent periodontitis cases and 73 controls.
- Analysis of complete blood counts including white blood cells, red blood cells, hemoglobin, and platelets.
- Multivariate linear regression used to analyze associations between hemogram variables and periodontitis severity indicators (probing depth, bleeding on probing).
Main Results:
- Adolescent periodontitis cases had a 5% higher mean platelet volume compared to controls.
- Subjects with deeper periodontal pockets (probing depth ≥4 mm) had 27% lower eosinophil counts.
- Increased mean platelet volume (7%) was associated with more severe periodontal pocketing.
Conclusions:
- Standard hematological tests did not reveal abnormalities in adolescents with periodontitis.
- Eosinophil counts and mean platelet volume may serve as potential indicators of periodontal inflammation in adolescents.
- Further research is warranted to explore the role of these hematological parameters in adolescent periodontitis.
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