Related Experiment Video

Updated: May 28, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

[Systemic and surgical management of metastatic renal cell carcinoma]

M W Kramer1, A S Merseburger, I Peters

  • 1Klinik für Urologie und Urologische Onkologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625 Hannover, Deutschland.

Der Urologe. Ausg. A
|October 20, 2011
PubMed

Insights

Targeted therapies and tyrosine kinase inhibitors have replaced cytokines for metastatic renal cell carcinoma (mRCC). This review explores current and emerging treatments, including sequential and combination therapies, for improved patient outcomes.

Area of Science:

  • Oncology
  • Pharmacology

Context:

  • Metastatic renal cell carcinoma (mRCC) treatment has evolved significantly with the advent of targeted therapies.
  • Cytokine-based treatments have been largely superseded by more effective targeted agents in first- and second-line settings.

Purpose:

  • To provide a comprehensive overview of current and emerging therapeutic strategies for metastatic renal cell carcinoma (mRCC).
  • To discuss the efficacy of sequential and combination therapies involving tyrosine kinase inhibitors (TKIs).
  • To review adjuvant, neoadjuvant, and surgical treatment alternatives for RCC.

Summary:

  • Several targeted therapies (sunitinib, bevacizumab, pazopanib, temsirolimus) are now standard for first-line treatment of mRCC, with others (sorafenib, pazopanib, everolimus) used in the second-line setting.
  • The review examines the potential benefits of sequential TKI therapies and combination regimens to enhance clinical outcomes.
  • Adjuvant, neoadjuvant, and surgical options for renal cell carcinoma (RCC) are also addressed.

Impact:

  • This review offers critical insights into optimizing treatment pathways for mRCC patients.
  • It highlights the shift towards personalized medicine and advanced therapeutic combinations.
  • Understanding these options is crucial for oncologists managing advanced RCC.

More Related Videos

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Related Concept Videos

Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...