Rapid determination of sample purity and composition by nanopore stochastic sensing

A rapid highly sensitive method to determine sample composition is reported. By monitoring the interaction between the sample of interest and a properly engineered nanopore, information regarding the identities and concentrations of the sample components could be revealed via their characteristic signatures, e.g., blockage amplitudes and event residence times. The sample composition method should be applicable in various research areas, including analytical chemistry, organic synthesis, pharmaceutical industry, etc.