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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Related Experiment Video

Updated: May 28, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Platelet proteomics.

Anne Zufferey1, Pierre Fontana, Jean-Luc Reny

  • 1Division of Angiology and Haemostasis, Department of Internal Medicine, Faculty of Medicine, University Hospitals of Geneva, Geneva, Switzerland.

Mass Spectrometry Reviews
|October 20, 2011
PubMed
Summary
This summary is machine-generated.

Platelet proteome analysis reveals key functions in hemostasis and thrombotic disorders. Comprehensive studies enhance understanding of platelet biology and identify new antiplatelet therapy targets.

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Last Updated: May 28, 2026

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LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
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LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

Area of Science:

  • Hematology
  • Proteomics
  • Molecular Biology

Background:

  • Platelets, small cell fragments from megakaryocytes, are crucial for hemostasis and thrombotic disorders.
  • They are involved in inflammation and wound repair, making them targets for antithrombotic therapies.
  • Platelet activation in circulation is triggered by pathways like subendothelial matrix and thrombin.

Purpose of the Study:

  • To explore the utility of platelet proteome analysis for understanding platelet biology and function.
  • To highlight the importance of experimental parameters like platelet quality and purity in proteomic studies.
  • To identify novel therapeutic targets for antiplatelet therapy by analyzing the platelet proteome.

Main Methods:

  • Utilizing various proteomic technologies for protein identification, characterization, localization, and quantification.
  • Integrating proteomics with metabolomics, transcriptomics, and bioinformatics for a multi-disciplinary approach.
  • Analyzing the platelet proteome under diverse experimental conditions.

Main Results:

  • Proteomic analysis provides deep insights into platelet protein composition and function.
  • Technical advancements in proteomics enable more detailed characterization of platelet proteins.
  • Interdisciplinary strategies enhance the understanding of complex platelet biological mechanisms.

Conclusions:

  • Comprehensive platelet proteome analysis is vital for understanding hemostasis and thrombotic disorders.
  • This approach can elucidate mechanisms in bleeding disorders and platelet hyperreactivity.
  • Identifying new therapeutic targets for antiplatelet therapy is a key outcome of platelet proteome research.