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Published on: May 10, 2021
Marginal resection for osteosarcoma with effective preoperative chemotherapy
Xiu-chun Yu1, Ming Xu, Ruo-xian Song
1Department of Orthopaedics, The General Hospital of Jinan Military Region, Jinan, China. yxch36@yahoo.com.cn
Orthopaedic Surgery
|October 20, 2011
Summary
Marginal resection combined with effective preoperative chemotherapy shows promising outcomes for osteosarcoma, achieving a low local recurrence rate and good limb function. This limb-sparing approach is recommended for experienced surgeons. Keywords: osteosarcoma, marginal resection, chemotherapy, limb salvage.
Area of Science:
- Orthopedic Oncology
- Surgical Oncology
- Medical Oncology
Background:
- Osteosarcoma is a primary bone malignancy often requiring aggressive treatment.
- Limb salvage surgery aims to preserve function while eradicating the tumor.
- Preoperative chemotherapy is crucial for managing localized osteosarcoma.
Purpose of the Study:
- To evaluate the clinical outcomes of marginal resection in osteosarcoma patients treated with effective preoperative chemotherapy.
- To assess local recurrence rates, metastasis, survival, and functional results.
Main Methods:
- Retrospective analysis of 38 osteosarcoma patients (1999-2008) undergoing marginal resection post-chemotherapy.
- Involved sites included distal femur, proximal tibia, proximal humerus, and proximal fibula.
- Various reconstruction methods were used, including allograft, prosthesis, and autograft implantation.
Main Results:
- A low local recurrence rate of 2.6% was observed.
- The 5-year overall survival rate was 74.7%, with an event-free survival rate of 60.8%.
- Excellent to good limb function was achieved in 60.5% of patients.
Conclusions:
- Marginal resection, when preceded by effective chemotherapy and careful evaluation, yields favorable results for osteosarcoma.
- This surgical technique should be performed by experienced surgeons proficient in limb salvage principles for osteosarcoma.
