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The use of bone morphogenetic protein 7 in fracture non-unions
Sven O'hEireamhoin1, John F Quinlan, Kieran O Rourke
1Department of Trauma and Orthopaedics, St. Vincent's University Hospital, Elm Park, Dublin, Ireland. svenerwin@hotmail.com
Objective:
To assess the rate of clinical and radiological union with the use of bone morphogenetic protein 7 (BMP-7) in a range of fractures.
Methods:
This case series retrospectively reviews a series of 16 fracture non-unions in 13 patients. These patients were treated with the commercially available BMP-7. Time to radiological and clinical union was assessed by serial out-patient follow-up.
Results:
At nine months post-surgery in which BMP-7 was added, 12 of 16 non-unions had achieved clinical and radiographic union. Three patients required repeat grafting. The mean time to union was 5.1 ± 1.6 months after the application of BMP-7.
Conclusion:
The use of the osteo-inductive agent, BMP-7 results in good clinical and radiological outcomes which are not restricted to tibial non-unions.
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